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Image Search Results
Journal: Cancer Research
Article Title: Development of Ewing's Sarcoma from Primary Bone Marrow–Derived Mesenchymal Progenitor Cells
doi: 10.1158/0008-5472.can-05-1696
Figure Lengend Snippet: Figure 4. Induction of p53 target genes in T1 and T2 tumor derived cells treated with 5-fluorouracil (5-FU) and the presence of p19ARF transcript in MPC wild type (wt) and their tumor-derived counterparts. A, Western blot analysis of p21 induction in MPCEWS-FLI-1-T1/T2-derived cells treated with 50 Ag/mL 5-fluorouracil or solvent (DMSO) for 16 hours, confirming the preservation of a functional p53 pathway. B, induction of p53 target genes in the same cells as in (A), as assessed by cDNA microarray analysis. C, semiquantitative RT-PCR analysis confirming the presence of a p19ARF transcript in wild-type MPC and its induction in the same cells overexpressing c-myc. No induction by c-myc is observed in p19ARF/ MPCs. D, presence of p19ARF in MPCEWS-FLI-1-T1/T2 tumor–derived cells, as assessed by RT-PCR.
Article Snippet: Primary mouse anti-V5 epitope mAb (Invitrogen), mouse anti-ErbB2 mAb (Chemicon, Temecula, CA),
Techniques: Derivative Assay, Western Blot, Solvent, Preserving, Functional Assay, Microarray, Reverse Transcription Polymerase Chain Reaction
Journal: British Journal of Cancer
Article Title: Characterisation of molecular events following cisplatin treatment of two curable ovarian cancer models: contrasting role for p53 induction and apoptosis in vivo
doi: 10.1038/sj.bjc.6602167
Figure Lengend Snippet: Microarray analysis of RNA samples from pretreatment tumours and 24 h post-CDDP-treatment (6 mg kg −1 i.p.). Each gene is spotted in duplicate on the array. Genes increased/decreased >2.5-fold by CDDP-treatment are indicated. For further details see Materials and Methods.
Article Snippet: The expression levels of 256 genes whose products are involved in the regulation of cell death and the cell cycle were profiled using a commercially available
Techniques: Microarray